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The Direct Formation of Glycosyl Thiols from Reducing Sugars Allows One‐Pot Protein Glycoconjugation
Author(s) -
Bernardes Gonçalo J. L.,
Gamblin David P.,
Davis Benjamin G.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600685
Subject(s) - glycosylation , glycosyl , chemistry , reagent , combinatorial chemistry , computer science , biochemistry , organic chemistry
Sweet and easy : A one‐pot method consisting of direct thionation (1) followed by thiol‐mediated chemoselective ligation (2) can be used for site‐selective protein glycosylation. This procedure, which uses the Lawesson reagent, has been shown to be fully compatible with unprotected sugars, the products of which can be directly used in a selenenylsulfide protein glycosylation strategy.