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Macrocyclization by Ring‐Closing Metathesis in the Total Synthesis of Natural Products: Reaction Conditions and Limitations
Author(s) -
Gradillas Ana,
PérezCastells Javier
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600641
Subject(s) - salt metathesis reaction , ring closing metathesis , total synthesis , reaction conditions , metathesis , compatibility (geochemistry) , combinatorial chemistry , chemistry , computer science , biochemical engineering , organic chemistry , catalysis , chemical engineering , engineering , polymerization , polymer
The construction of macrocycles by ring‐closing metathesis (RCM) is often used as the key step in the synthesis of natural products containing large rings. This reaction is attractive because of its high functional group compatibility and the possibility for further transformations. The finding of suitable reaction conditions is critical for the success of the synthesis. In this Minireview we summarize the efforts of many research groups to develop efficient RCM reactions on their way towards the total synthesis of natural macrocyclic products. Their findings should help in future synthesis to reduce the time‐consuming phase of the optimization of the reaction conditions.