Rhodium‐Catalyzed Propargylic Substitution: A Divergent Approach to Propargylic and Allenyl Sulfonamides | Zendy

Evans P. Andrew | Zendy; Lawler Michael J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Rhodium‐Catalyzed Propargylic Substitution: A Divergent Approach to Propargylic and Allenyl Sulfonamides

Author(s) -

Evans P. Andrew,

Lawler Michael J.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200600615

Subject(s) - amination , isomerization , rhodium , aryl , catalysis , chemistry , substitution (logic) , combinatorial chemistry , organic chemistry , medicinal chemistry , computer science , programming language , alkyl

Construction work : Rh‐catalyzed propargylic amination provides an efficient, versatile method for the preparation of aliphatic propargylic sulfonamides. This Rh‐catalyzed variant has a divergent nature, from which aryl‐substituted propargylic and allenyl sulfonamides can be constructed. A one‐pot two‐component Rh‐catalyzed propargylic amination/isomerization followed by a [4+2] carbocyclization demonstrates the synthetic utility of this divergent behavior.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research