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Modular Asymmetric Synthesis of Aigialomycin D, a Kinase‐Inhibitory Scaffold
Author(s) -
Barluenga Sofia,
Dakas PierreYves,
Ferandin Yoan,
Meijer Laurent,
Winssinger Nicolas
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600593
Subject(s) - class (philosophy) , modular design , cyclin dependent kinase 1 , natural product , kinase , computer science , inhibitory postsynaptic potential , product (mathematics) , chemistry , information retrieval , biochemistry , biology , mathematics , neuroscience , artificial intelligence , cell cycle , cell , programming language , geometry
On solid ground : Despite no obvious resemblance to adenosine analogues, the family of resorcyclic macrolides contains a high proportion of kinase and ATPase inhibitors. A solid‐phase total synthesis of aigialomycin D extends the diversity of this class of natural product. Aigialomycin was found to inhibit CDK1/5 and GSK. EOM=ethoxymethyl.
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