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Alcohols in Isonitrile‐Based Multicomponent Reaction: Passerini Reaction of Alcohols in the Presence of O ‐Iodoxybenzoic Acid
Author(s) -
Ngouansavanh Tifelle,
Zhu Jieping
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600588
Subject(s) - chemistry , organic chemistry , reaction conditions , catalysis , combinatorial chemistry
High proof : An alcohol instead of an aldehyde is an effective reaction partner in the Passerini reaction (P‐3CR) in the presence of O ‐iodoxybenzoic acid (IBX). Thus, by simply heating a solution of an alcohol, a carboxylic acid, an isonitrile, and IBX at 40 °C, an oxidation/P‐3CR sequence occurred smoothly to afford the α‐acyloxy carboxamide in good‐to‐excellent yield.
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