Premium
Towards a General Scale of Nucleophilicity?
Author(s) -
Phan Thanh Binh,
Breugst Martin,
Mayr Herbert
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600542
Subject(s) - nucleophile , carbocation , sn2 reaction , chemistry , scale (ratio) , reaction rate constant , computational chemistry , medicinal chemistry , physics , organic chemistry , kinetics , quantum mechanics , catalysis
One for all? The nucleophilicity parameters N , which have been derived from the rate constants k of reactions of nucleophiles with carbocations, also hold for S N 2‐type reactions (see scheme). A general equation is suggested which includes established correlations (Swain–Scott, Ritchie) as special cases.