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Building Complex Glycopeptides: Development of a Cysteine‐Free Native Chemical Ligation Protocol
Author(s) -
Wu Bin,
Chen Jiehao,
Warren J. David,
Chen Gong,
Hua Zihao,
Danishefsky Samuel J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600538
Subject(s) - native chemical ligation , glycosylation , glycopeptide , cysteine , chemistry , glycobiology , biochemistry , glycoprotein , computational biology , combinatorial chemistry , biology , enzyme , glycan , antibiotics
The missing link : Reiterative ligations based on non‐cysteine and cysteine‐based acyl acceptors have been used to prepare synthetic polypeptides and proteins with multiple sites of glycosylation. Highly complex positionally defined glycopolypeptides corresponding to single glycoforms can be formed from simple components.