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Premithramycinone G, an Early Shunt Product of the Mithramycin Biosynthetic Pathway Accumulated upon Inactivation of Oxygenase MtmOII
Author(s) -
Abdelfattah Mohamed S.,
Rohr Jürgen
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600511
Subject(s) - oxygenase , chemistry , stereochemistry , ring (chemistry) , biochemistry , biosynthesis , gene , organic chemistry
The unusual dodecaketide premithramycinone G (see formula), which possesses a five‐membered ring with two ketide chains in its tetracyclic structure, was accumulated upon inactivation of an early acting oxygenase of the mithramycin biosynthetic pathway. This unexpected structure allows novel hypothetic conclusions to be drawn regarding the early mithramycin pathway and suggestions for the involvement of three previously unassigned oxygenases.