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A Highly Active Catalyst for Suzuki–Miyaura Cross‐Coupling Reactions of Heteroaryl Compounds
Author(s) -
Billingsley Kelvin L.,
Anderson Kevin W.,
Buchwald Stephen L.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600493
Subject(s) - catalysis , pyridine , chemistry , pyrrole , indole test , halide , combinatorial chemistry , aminopyridines , organic chemistry
Unprecedented activity : Catalysts derived from Pd and bulky dialkylphosphinobiaryl ligands are shown to be highly stable and active in Suzuki–Miyaura reactions of heteroaryl halides and heteroaryl boronic acids/esters (e.g., 3‐ or 4‐pyridine, indole, and N‐protected pyrrole derivatives). Furthermore, this catalyst system is not inhibited by the presence of highly basic aminopyridines or aminopyrimidines.