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Construction of Enantiomerically Enriched Tertiary α‐Hydroxycarboxylic Acid Derivatives by Phase‐Transfer‐Catalyzed Asymmetric Alkylation of Diaryloxazolidin‐2,4‐diones
Author(s) -
Ooi Takashi,
Fukumoto Kazuhiro,
Maruoka Keiji
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600470
Subject(s) - alkylation , enantioselective synthesis , ammonium bromide , catalysis , ether , ammonium , bromide , chemistry , organic chemistry , phase transfer catalyst , optically active , phase (matter) , combinatorial chemistry , biochemistry , pulmonary surfactant
Center of attention : The chiral ammonium bromide 1 has been used as a catalyst for the highly enantioselective alkylation of diaryloxazolidindiones 2 under mild phase‐transfer conditions (TBME= tert ‐butyl methyl ether). This method provides practical access to a variety of optically active tertiary α‐hydroxycarboxylic acid derivatives.