Construction of Enantiomerically Enriched Tertiary α‐Hydroxycarboxylic Acid Derivatives by Phase‐Transfer‐Catalyzed Asymmetric Alkylation of Diaryloxazolidin‐2,4‐diones | Zendy

Ooi Takashi | Zendy; Fukumoto Kazuhiro | Zendy; Maruoka Keiji | Zendy

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Construction of Enantiomerically Enriched Tertiary α‐Hydroxycarboxylic Acid Derivatives by Phase‐Transfer‐Catalyzed Asymmetric Alkylation of Diaryloxazolidin‐2,4‐diones

Author(s) -

Ooi Takashi,

Fukumoto Kazuhiro,

Maruoka Keiji

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200600470

Subject(s) - alkylation , enantioselective synthesis , ammonium bromide , catalysis , ether , ammonium , bromide , chemistry , organic chemistry , phase transfer catalyst , optically active , phase (matter) , combinatorial chemistry , biochemistry , pulmonary surfactant

Center of attention : The chiral ammonium bromide 1 has been used as a catalyst for the highly enantioselective alkylation of diaryloxazolidindiones 2 under mild phase‐transfer conditions (TBME= tert ‐butyl methyl ether). This method provides practical access to a variety of optically active tertiary α‐hydroxycarboxylic acid derivatives.

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