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Towards a Structural Understanding of the Anti‐Ulcer and Anti‐Gastritis Drug Bismuth Subsalicylate
Author(s) -
Andrews Philip C.,
Deacon Glen B.,
Forsyth Craig M.,
Junk Peter C.,
Kumar Ish,
Maguire Melissa
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600469
Subject(s) - bismuth , gastritis , chemistry , cluster (spacecraft) , drug , gastroenterology , crystallography , medicine , helicobacter pylori , pharmacology , organic chemistry , computer science , programming language
The action of Pepto‐Bismol arising from the structure and hydrolysis of bismuth subsalicylate (BSS) is not yet understood. Two bismuth oxosalicylate clusters, [Bi 38 O 44 (HSal) 26 (Me 2 CO) 16 (H 2 O) 2 ] ( 1 ) and [Bi 9 O 7 (HSal) 13 (Me 2 CO) 5 ] ( 2 ), have been characterized which provide structural insight into the nature of BSS. A Bi 9 O 7 cluster forms the core of 2 and is found at the heart of 1 (see picture; core Bi atoms: green, core O atoms: red).