Towards a Structural Understanding of the Anti‐Ulcer and Anti‐Gastritis Drug Bismuth Subsalicylate | Zendy

Andrews Philip C. | Zendy; Deacon Glen B. | Zendy; Forsyth Craig M. | Zendy; Junk Peter C. | Zendy; Kumar Ish | Zendy; Maguire Melissa | Zendy

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Towards a Structural Understanding of the Anti‐Ulcer and Anti‐Gastritis Drug Bismuth Subsalicylate

Author(s) -

Andrews Philip C.,

Deacon Glen B.,

Forsyth Craig M.,

Junk Peter C.,

Kumar Ish,

Maguire Melissa

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200600469

Subject(s) - bismuth , gastritis , chemistry , cluster (spacecraft) , drug , gastroenterology , crystallography , medicine , helicobacter pylori , pharmacology , organic chemistry , computer science , programming language

The action of Pepto‐Bismol arising from the structure and hydrolysis of bismuth subsalicylate (BSS) is not yet understood. Two bismuth oxosalicylate clusters, [Bi 38 O 44 (HSal) 26 (Me 2 CO) 16 (H 2 O) 2 ] ( 1 ) and [Bi 9 O 7 (HSal) 13 (Me 2 CO) 5 ] ( 2 ), have been characterized which provide structural insight into the nature of BSS. A Bi 9 O 7 cluster forms the core of 2 and is found at the heart of 1 (see picture; core Bi atoms: green, core O atoms: red).

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