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Self‐Assembled Signaling Aptamer DNA Arrays for Protein Detection
Author(s) -
Lin Chenxiang,
Katilius Evaldas,
Liu Yan,
Zhang Junping,
Yan Hao
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600438
Subject(s) - aptamer , dna , fluorescence microscope , confocal microscopy , nanotechnology , confocal , fluorescence , biosensor , tile , dna microarray , chemistry , protein detection , biophysics , microbiology and biotechnology , materials science , biology , biochemistry , gene , gene expression , physics , geometry , mathematics , quantum mechanics , composite material
Sticking the tiles : A DNA‐tile‐directed self‐assembly of signaling aptamers into high‐density nanoarrays allows subnanomolar detection of protein molecules by using confocal fluorescence microscopy imaging. This water‐soluble aptamer microarray provides a novel strategy for developing programmable sensor arrays.