Premium
Control of Amyloid β‐Peptide Protofibril Formation by a Designed Template Assembly
Author(s) -
Dolphin Gunnar T.,
Dumy Pascal,
Garcia Julian
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600395
Subject(s) - peptide , amyloid fibril , fibril , amyloid (mycology) , kinetics , computer science , chemistry , biophysics , nanotechnology , computational biology , biochemistry , crystallography , materials science , amyloid β , biology , medicine , physics , disease , inorganic chemistry , quantum mechanics
Insight into amyloids : Four identical segments of the amyloid β‐peptide, which is associated with Alzheimer's disease by fibril formation, were successfully attached to a cyclic decapeptide template. The assembly forms soluble protofibrils (see picture) that reveal a cross‐β‐sheet structure, with fast controllable kinetics and without a lag phase.