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Highly Enantioselective Aza‐Baylis–Hillman Reaction in a Chiral Reaction Medium
Author(s) -
Gausepohl Rolf,
Buskens Pascal,
Kleinen Jochen,
Bruckmann Angelika,
Lehmann Christian W.,
Klankermayer Jürgen,
Leitner Walter
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600327
Subject(s) - enantioselective synthesis , ionic liquid , chirality (physics) , chemistry , baylis–hillman reaction , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark
Let's twist again! The first highly enantioselective asymmetric reaction in which a chiral reaction medium is the sole source of chirality is presented. The aza‐Baylis–Hillman reaction in an ionic liquid with a chiral anion, whose design is based on mechanistic insights, gave products with up to 84 % ee.