Highly Enantioselective Aza‐Baylis–Hillman Reaction in a Chiral Reaction Medium | Zendy

Gausepohl Rolf | Zendy; Buskens Pascal | Zendy; Kleinen Jochen | Zendy; Bruckmann Angelika | Zendy; Lehmann Christian W. | Zendy; Klankermayer Jürgen | Zendy; Leitner Walter | Zendy

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Highly Enantioselective Aza‐Baylis–Hillman Reaction in a Chiral Reaction Medium

Author(s) -

Gausepohl Rolf,

Buskens Pascal,

Kleinen Jochen,

Bruckmann Angelika,

Lehmann Christian W.,

Klankermayer Jürgen,

Leitner Walter

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200600327

Subject(s) - enantioselective synthesis , ionic liquid , chirality (physics) , chemistry , baylis–hillman reaction , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , chiral symmetry , physics , quantum mechanics , nambu–jona lasinio model , quark

Let's twist again! The first highly enantioselective asymmetric reaction in which a chiral reaction medium is the sole source of chirality is presented. The aza‐Baylis–Hillman reaction in an ionic liquid with a chiral anion, whose design is based on mechanistic insights, gave products with up to 84 % ee.

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