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A New Class of Biochemically Degradable, Stimulus‐Responsive Triblock Copolymer Gelators
Author(s) -
Li Chengming,
Madsen Jeppe,
Armes Steven P.,
Lewis Andrew L.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600324
Subject(s) - copolymer , atom transfer radical polymerization , polymerization , disulfide bond , polymer chemistry , chemistry , bifunctional , polymer science , organic chemistry , polymer , catalysis , biochemistry
To rub gel into the wound : A thermoresponsive ABA triblock copolymer gelator with A= N ‐isopropylacrylamide and B=2‐(methacryloyloxy)ethyl phosphorylcholine has been synthesized by atom transfer radical polymerization by using a bifunctional disulfide‐based initiator. This triblock copolymer forms free‐standing peptide‐degradable micellar gels under physiologically relevant conditions.