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Design, Synthesis, and Membrane‐Translocation Studies of Inositol‐Based Transporters
Author(s) -
Maiti Kaustabh K.,
Jeon OckYoum,
Lee Woo Sirl,
Kim DongChan,
Kim KyongTai,
Takeuchi Toshihide,
Futaki Shiroh,
Chung SungKee
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600312
Subject(s) - chromosomal translocation , inositol , transporter , membrane , in vivo , in vitro , chemistry , microbiology and biotechnology , biochemistry , biophysics , computational biology , biology , receptor , gene , genetics
Delivery vehicles : Novel guanidine‐containing “transporters” constructed on a dimeric inositol scaffold show significant translocation across the cell membrane and the blood–brain barrier, as well as unique in vitro and in vivo distributions. Doxorubicin was efficiently delivered to mouse‐brain tissue by conjugating the compound with such a transporter (see the fluorescence microscopy image).