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Catalytic Enantioselective Crossed Aldehyde–Ketone Benzoin Cyclization
Author(s) -
Takikawa Hiroshi,
Hachisu Yoshifumi,
Bode Jeffrey W.,
Suzuki Keisuke
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600268
Subject(s) - benzoin , enantioselective synthesis , aldehyde , ketone , catalysis , chemistry , organic chemistry , combinatorial chemistry
Joining together : The catalytic, asymmetric benzoin cyclization of a wide variety ketoaldehydes using chiral triazolium salts of type 1 has been carried out (see scheme). The corresponding cyclized products were prepared in high yields and with excellent enantioselectivities.