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Short Oxo–Titanium( IV ) Bond in Bacterial Transferrin: A Protein Target for Metalloantibiotics
Author(s) -
Guo Maolin,
Harvey Ian,
Campopiano Dominic J.,
Sadler Peter J.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600260
Subject(s) - transferrin , ferric , chemistry , biochemistry , computational biology , food science , biology , inorganic chemistry
A competitive edge? Ti IV binding to a bacterial transferrin (ferric‐ion‐binding protein, FBP; see picture, foreground) is rapid, competes with Fe III binding, and results in a short oxo–Ti IV bond (EXAFS studies; see picture, background). Inhibitors of iron uptake by FBP should be active against diseases caused by bacterial pathogens. The results suggest that Ti complexes could provide such inhibition.