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Trichloromethyl Ketones as Synthetically Versatile Donors: Application in Direct Catalytic Mannich‐Type Reactions and the Stereoselective Synthesis of Azetidines
Author(s) -
Morimoto Hiroyuki,
Wiedemann Sean H.,
Yamaguchi Akitake,
Harada Shinji,
Chen Zhihua,
Matsunaga Shigeki,
Shibasaki Masakatsu
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600227
Subject(s) - stereoselectivity , nucleophile , adduct , chemistry , intermolecular force , catalysis , mannich reaction , yield (engineering) , combinatorial chemistry , organic chemistry , medicinal chemistry , molecule , materials science , metallurgy
Chemical transformers! Catalytic nucleophilic activation of trichloromethyl ketones allows applications in intermolecular carbon–carbon bond‐forming reactions. Mannich adducts such as azetidines can be obtained from the primary products in high yield and syn selectivity. PG=protecting group.