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Highly Enantioselective Conjugate Reduction of β,β‐Disubstituted α,β‐Unsaturated Nitriles
Author(s) -
Lee Daehyung,
Kim Daesung,
Yun Jaesook
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600184
Subject(s) - conjugate , enantioselective synthesis , chemistry , aryl , reduction (mathematics) , combinatorial chemistry , ligand (biochemistry) , copper , organic chemistry , mathematics , catalysis , receptor , biochemistry , mathematical analysis , alkyl , geometry
Easy access : The highly enantioselective conjugate reduction of α,β‐unsaturated nitriles is achieved by employing bench‐top stable copper( II ) acetate and josiphos (L) as the ligand in the presence of polymethylhydrosiloxane (PMHS). This protocol provides ready access to valuable chiral β‐aryl substituted nitriles in good yields and with excellent enantioselectivities.