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Introduction of 2,2,2‐Trichloroethyl‐Protected Sulfates into Monosaccharides with a Sulfuryl Imidazolium Salt and Application to the Synthesis of Sulfated Carbohydrates
Author(s) -
Ingram Laura J.,
Taylor Scott D.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600153
Subject(s) - monosaccharide , sulfation , chemistry , trifluoromethanesulfonate , salt (chemistry) , sulfur , organic chemistry , combinatorial chemistry , catalysis , biochemistry
Sweet sulfur : Sulfuryl imidazolium salt 1 represents a new class of highly potent sulfating agents and is very effective for introducing trichloroethyl‐protected sulfates into monosaccharides for the synthesis of sulfated oligosaccharides (see scheme; NMI= N ‐methylimidazole, OTf=triflate, PG=protecting group, TCE=2,2,2‐trichloroethyl).