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Chemoselective Benzylic CH Activations for the Preparation of Condensed N‐Heterocycles
Author(s) -
Ren Hongjun,
Knochel Paul
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600111
Subject(s) - domino , ligand (biochemistry) , chemistry , chemoselectivity , combinatorial chemistry , range (aeronautics) , content (measure theory) , computer science , catalysis , medicinal chemistry , organic chemistry , materials science , mathematics , biochemistry , receptor , mathematical analysis , composite material
Buttoning up : A chemoselective domino reaction including one or two successive CH activations serves to convert a range of readily available N‐arylpyrroles into complex polycondensed N‐heterocycles. The reaction is catalyzed by Pd(OAc) 2 (5 mol %), and p ‐Tol 3 P (10 mol %) is added as the ligand (see scheme; Tol=tolyl).