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Evolving Proteins of Novel Composition
Author(s) -
Montclare Jin Kim,
Tirrell David A.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600088
Subject(s) - composition (language) , amino acid , computational biology , chemistry , residue (chemistry) , information loss , computer science , biochemistry , biology , philosophy , artificial intelligence , linguistics
Changing its nature : Global incorporation of noncanonical amino acids can alter the behavior of proteins in useful ways. In some cases, however, replacement of natural amino acids by noncanonical analogues (blue bars in picture) can cause loss of protein stability. After several generations, functional proteins of non‐natural composition were prepared through residue‐specific incorporation combined with directed evolution.