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DNA Polymerization on Gold Nanoparticles through Rolling Circle Amplification: Towards Novel Scaffolds for Three‐Dimensional Periodic Nanoassemblies
Author(s) -
Zhao Weian,
Gao Yan,
Kandadai Srinivas A.,
Brook Michael A.,
Li Yingfu
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200600061
Subject(s) - rolling circle replication , nanotechnology , colloidal gold , biosensor , nanostructure , dna , polymerization , materials science , nanoparticle , complementary sequences , molecule , chemistry , polymer , dna polymerase , biochemistry , statistics , mathematics , organic chemistry , composite material
Ever‐increasing through circles : Long single‐stranded DNA molecules with repetitive sequence units were synthesized on gold nanoparticles through rolling circle amplification (RCA, see scheme). These special DNA–AuNP conjugates were then used as a scaffold for assembling periodic 3D nanostructures, which may find applications in nanocomputing devices, nanoelectronic circuits, and ultrasensitive biosensors.