Cover Picture: On the Remarkable Antitumor Properties of Fludelone: How We Got There (Angew. Chem. Int. Ed. 19/2005) | Zendy

Rivkin Alexey | Zendy; Chou TingChao | Zendy; Danishefsky Samuel J. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Cover Picture: On the Remarkable Antitumor Properties of Fludelone: How We Got There (Angew. Chem. Int. Ed. 19/2005)

Author(s) -

Rivkin Alexey,

Chou TingChao,

Danishefsky Samuel J.

Publication year - 2005

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200590063

Subject(s) - cover (algebra) , computational biology , biological activity , int , nude mouse , chemistry , combinatorial chemistry , medicine , stereochemistry , biochemistry , biology , computer science , engineering , in vitro , mechanical engineering , operating system

Synthetic and biological studies of epothilone B (isolated from a myxobacterium) led to the discovery of a 26‐trifluoro analogue that is remarkably active in treating xenograft tumors in nude mice. These findings underscore the potential of using natural products as leads, in conjunction with directed total synthesis, in the quest for new drugs. S. J. Danishefsky and co‐workers present their synthetic strategy along with biological data in their Minireview on page 2838 ff.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research