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Cover Picture: On the Remarkable Antitumor Properties of Fludelone: How We Got There (Angew. Chem. Int. Ed. 19/2005)
Author(s) -
Rivkin Alexey,
Chou TingChao,
Danishefsky Samuel J.
Publication year - 2005
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200590063
Subject(s) - cover (algebra) , computational biology , biological activity , int , nude mouse , chemistry , combinatorial chemistry , medicine , stereochemistry , biochemistry , biology , computer science , engineering , in vitro , mechanical engineering , operating system
Synthetic and biological studies of epothilone B (isolated from a myxobacterium) led to the discovery of a 26‐trifluoro analogue that is remarkably active in treating xenograft tumors in nude mice. These findings underscore the potential of using natural products as leads, in conjunction with directed total synthesis, in the quest for new drugs. S. J. Danishefsky and co‐workers present their synthetic strategy along with biological data in their Minireview on page 2838 ff.