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Cover Picture: Palladium‐Catalyzed Enantioselective Domino Reaction for the Efficient Synthesis of Vitamin E (Angew. Chem. Int. Ed. 2/2005)
Author(s) -
Tietze Lutz F.,
Sommer Konrad M.,
Zinngrebe Julia,
Stecker Florian
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200590003
Subject(s) - enantioselective synthesis , domino , palladium , catalysis , chemistry , int , combinatorial chemistry , stereochemistry , organic chemistry , computer science , programming language
A domino reaction consists of several consecutive transformations in which the functions required for one reaction are generated in the preceding bond‐formation or fragmentation step. L. F. Tietze et al. applied this concept to the synthesis of vitamin E described on page 257 ff. They developed an enantioselective palladium‐catalyzed process for the construction of the chiral chroman framework with 96 % ee and concomitant introduction of part of the side chain.