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Cover Picture: Expanding the Genetic Code (Angew. Chem. Int. Ed. 1/2005)
Author(s) -
Wang Lei,
Schultz Peter G.
Publication year - 2004
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200590000
Subject(s) - genetic code , amino acid , cover (algebra) , int , computational biology , code (set theory) , function (biology) , genetics , biology , chemistry , computer science , programming language , engineering , mechanical engineering , set (abstract data type)
Unnatural amino acids can be incorporated as new building blocks into the genetic codes of both prokaryotic and eukaryotic organisms to facilitate studies of protein structure and function. Over 30 unnatural amino acids with modified side chains have been genetically encoded in response to unique triplet and quadruplet codons. L. Wang and P. G. Schultz describe in their Review on page 34 ff. chemical and biochemical approaches that have been developed to manipulate protein structure and add new amino acids to the genetic code.