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Total Synthesis of Auripyrone A
Author(s) -
Lister Troy,
Perkins Michael V.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504573
Subject(s) - computer science
A natural conclusion : An efficient, asymmetric synthesis of the cytotoxic marine polypropionate auripyrone A ( 1 ) was achieved from ketone 2 and aldehyde 3 , and the absolute stereochemistry of the natural product was established. The strategy employs substrate control to develop the stereopentad unit.