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Room‐Temperature Nucleophilic Aromatic Fluorination: Experimental and Theoretical Studies
Author(s) -
Sun Haoran,
DiMagno Stephen G.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504555
Subject(s) - nucleophile , chemistry , computational chemistry , organic chemistry , catalysis
Taming the reagent : The use of anhydrous tetrabutylammonium fluoride (TBAF anh ) in nucleophilic aromatic substitution reactions, including variants of the selective halogen‐exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAF anh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.