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Using Nonnatural Amino Acids to Control Metal‐Coordination Number in Three‐Stranded Coiled Coils
Author(s) -
Lee KyungHoon,
Cabello Chris,
Hemmingsen Lars,
Marsh E. Neil G.,
Pecoraro Vincent L.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504548
Subject(s) - alanine , residue (chemistry) , penicillamine , amino acid , cysteine , chemistry , stereochemistry , leucine , sequence (biology) , metal , biochemistry , organic chemistry , enzyme
It isn't natural : TRI peptides can selectively control the coordination number of a metal center by changing only one of the amino acids in the primary sequence. Replacement of the cysteine residue with penicillamine leads to a three‐coordinate complex Cd II S 3 , whereas substitution of alanine for leucine gives four‐coordinate CdS 3 O (see scheme).
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