Premium
Multivalent Dendrons for High‐Affinity Adhesion of Proteins to DNA
Author(s) -
Kostiainen Mauri A.,
Szilvay Géza R.,
Smith David K.,
Linder Markus B.,
Ikkala Olli
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504540
Subject(s) - dendrimer , spermine , chemistry , dna , conjugate , polyamine , dispersity , combinatorial chemistry , biophysics , biochemistry , polymer chemistry , biology , mathematics , enzyme , mathematical analysis
Strength in numbers: Multivalent dendrons that have an N ‐maleimido group at the focal point can be used to construct monodisperse one‐to‐one protein–dendron conjugates. The second generation polyamine dendron with spermine surface groups clearly imparts its high‐affinity DNA binding to a protein of choice.