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Regulating Supramolecular Function in Membranes: Calixarenes that Enable or Inhibit Transmembrane Cl − Transport
Author(s) -
Seganish Jennifer L.,
Santacroce Paul V.,
Salimian Kevan J.,
Fettinger James C.,
Zavalij Peter,
Davis Jeffery T.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504489
Subject(s) - calixarene , supramolecular chemistry , membrane , chemistry , phospholipid , transporter , transmembrane protein , amide , membrane transport , chloride , biophysics , biochemistry , molecule , organic chemistry , receptor , biology , gene
Self‐assembled transporter : Self‐association of a partial‐cone calixarene amide provides membrane‐active aggregates that enable the transport of chloride anions across phospholipid membranes (see picture). Additionally, a regulatory system is described, wherein an inactive calixarene analogue inhibits the active chloride transporter.