Regulating Supramolecular Function in Membranes: Calixarenes that Enable or Inhibit Transmembrane Cl −  Transport | Zendy

Seganish Jennifer L. | Zendy; Santacroce Paul V. | Zendy; Salimian Kevan J. | Zendy; Fettinger James C. | Zendy; Zavalij Peter | Zendy; Davis Jeffery T. | Zendy

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Regulating Supramolecular Function in Membranes: Calixarenes that Enable or Inhibit Transmembrane Cl − Transport

Author(s) -

Seganish Jennifer L.,

Santacroce Paul V.,

Salimian Kevan J.,

Fettinger James C.,

Zavalij Peter,

Davis Jeffery T.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200504489

Subject(s) - calixarene , supramolecular chemistry , membrane , chemistry , phospholipid , transporter , transmembrane protein , amide , membrane transport , chloride , biophysics , biochemistry , molecule , organic chemistry , receptor , biology , gene

Self‐assembled transporter : Self‐association of a partial‐cone calixarene amide provides membrane‐active aggregates that enable the transport of chloride anions across phospholipid membranes (see picture). Additionally, a regulatory system is described, wherein an inactive calixarene analogue inhibits the active chloride transporter.

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