Protected  32 P‐Labels in Deoxyribonucleotides: Investigation of Sequence Selectivity of DNA Photocleavage by Enediyne–, Fulvene–, and Acetylene–Lysine Conjugates | Zendy

Breiner Boris | Zendy; Schlatterer Jörg C. | Zendy; Kovalenko Serguei V. | Zendy; Greenbaum Nancy L. | Zendy; Alabugin Igor V. | Zendy

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Protected 32 P‐Labels in Deoxyribonucleotides: Investigation of Sequence Selectivity of DNA Photocleavage by Enediyne–, Fulvene–, and Acetylene–Lysine Conjugates

Author(s) -

Breiner Boris,

Schlatterer Jörg C.,

Kovalenko Serguei V.,

Greenbaum Nancy L.,

Alabugin Igor V.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200504479

Subject(s) - enediyne , chemistry , selectivity , fulvene , dna , acetylene , conjugated system , conjugate , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , polymer , mathematical analysis , mathematics , catalysis

Finding a compromise : The sequence selectivity of DNA photocleavage by enediyne–, acetylene–, and fulvene–lysine conjugates was investigated by using labeled DNA oligomers. Since the external 32 P label was removed by these photocleavers, the label was protected by translocation inside the oligomer (see figure). The selectivity of cleavage is controlled by a compromise between AT selectivity for binding and G selectivity for electron transfer.

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