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Protected 32 P‐Labels in Deoxyribonucleotides: Investigation of Sequence Selectivity of DNA Photocleavage by Enediyne–, Fulvene–, and Acetylene–Lysine Conjugates
Author(s) -
Breiner Boris,
Schlatterer Jörg C.,
Kovalenko Serguei V.,
Greenbaum Nancy L.,
Alabugin Igor V.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504479
Subject(s) - enediyne , chemistry , selectivity , fulvene , dna , acetylene , conjugated system , conjugate , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , polymer , mathematical analysis , mathematics , catalysis
Finding a compromise : The sequence selectivity of DNA photocleavage by enediyne–, acetylene–, and fulvene–lysine conjugates was investigated by using labeled DNA oligomers. Since the external 32 P label was removed by these photocleavers, the label was protected by translocation inside the oligomer (see figure). The selectivity of cleavage is controlled by a compromise between AT selectivity for binding and G selectivity for electron transfer.