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A Highly Enantioselective Brønsted Acid Catalyst for the Strecker Reaction
Author(s) -
Rueping Magnus,
Sugiono Erli,
Azap Cengiz
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504344
Subject(s) - hydrocyanation , enantioselective synthesis , strecker amino acid synthesis , chemistry , catalysis , iminium , brønsted–lowry acid–base theory , imine , organic chemistry , nitrile , combinatorial chemistry
An amenable route to amino acids : An optimized new chiral binol phosphate catalyst (see scheme; Ar=9‐phenanthryl) for the hydrocyanation of imines provides a convenient strategy for the enantioselective synthesis of α‐amino acids and diamines.