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Stereochemical Uniformity in Marine Polyether Ladders—Implications for the Biosynthesis and Structure of Maitotoxin
Author(s) -
Gallimore Andrew R.,
Spencer Jonathan B.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504284
Subject(s) - ciguatoxin , ciguatera , dinoflagellate , polyketide , marine toxin , stereochemistry , natural product , chemistry , biosynthesis , fish <actinopterygii> , biology , toxin , organic chemistry , ecology , biochemistry , enzyme , fishery
Odd one out : Marine polyether ladders are probably the most well‐known of all marine natural products, not only for their fascinating structures, but also for their characteristic toxicity. A very straightforward model for the biosynthesis of all known polyether ladders, including maitotoxin (the largest and most toxic of this structural family; see formula) is described, but is the structure of this giant molecule really known?