Premium
A Catalytic, Me 2 Zn‐Mediated, Enantioselective Reformatsky Reaction With Ketones
Author(s) -
Cozzi Pier Giorgio
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504239
Subject(s) - enantioselective synthesis , ketone , stereocenter , electrophile , catalysis , reformatsky reaction , chemistry , combinatorial chemistry , scope (computer science) , computer science , organic chemistry , programming language
Kill two birds with one … Salen! A catalytic and practical Me 2 Zn‐mediated enantioselective Reformatsky reaction promoted by [ClMn(salen)] with a ketone as the electrophile is presented (see scheme). The broad scope and simple nature of this procedure, which allows the use of commercially available starting materials and leads to useful building blocks containing quaternary stereocenters, make it extremely attractive. (salen= N , N ′‐ethylenebis(salicylideneamine).)