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Regiospecific CH Bond Activation: Reversible H/D Exchange Promoted by Cu I Complexes with Triazamacrocyclic Ligands
Author(s) -
Ribas Xavi,
Xifra Raül,
Parella Teodor,
Poater Albert,
Solà Miquel,
Llobet Antoni
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504222
Subject(s) - chemistry , medicinal chemistry , stereochemistry , crystallography
The first reversible and regiospecific H/D exchange promoted by Cu I proceeds in weakly coordinating deuterated “acidic” solvents, such as [D 6 ]acetone or [D 4 ]methanol (see scheme). The kinetics of the reaction have been studied in both directions (H/D and D/H exchange) by 1 H and 2 H NMR spectroscopy, and a molecular mechanism is proposed that is in accordance with all experimental and theoretical data.