Premium
Regiospecific CH Bond Activation: Reversible H/D Exchange Promoted by Cu I Complexes with Triazamacrocyclic Ligands
Author(s) -
Ribas Xavi,
Xifra Raül,
Parella Teodor,
Poater Albert,
Solà Miquel,
Llobet Antoni
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504222
Subject(s) - chemistry , medicinal chemistry , stereochemistry , crystallography
The first reversible and regiospecific H/D exchange promoted by Cu I proceeds in weakly coordinating deuterated “acidic” solvents, such as [D 6 ]acetone or [D 4 ]methanol (see scheme). The kinetics of the reaction have been studied in both directions (H/D and D/H exchange) by 1 H and 2 H NMR spectroscopy, and a molecular mechanism is proposed that is in accordance with all experimental and theoretical data.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom