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Modulation of DNA Constraints That Control Macromolecular Folding
Author(s) -
Miduturu Chandrasekhar V.,
Silverman Scott K.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504124
Subject(s) - macromolecule , dna , folding (dsp implementation) , aptamer , rna , control (management) , computational biology , modulation (music) , computer science , variety (cybernetics) , chemistry , biology , biochemistry , physics , gene , engineering , genetics , artificial intelligence , electrical engineering , acoustics
Taking control with DNA : Covalently attached double‐stranded DNA constraints can control the conformations of other macromolecules. A variety of approaches (including competitive ligand–aptamer interactions) were used to modulate the effects of such constraints on the structure of a large RNA molecule.