A Practical Approach to the Resolution of Racemic  N ‐Benzyl α‐Amino Acids by Liquid–Liquid Extraction with a Lipophilic Chiral Salen–Cobalt( III ) Complex | Zendy

Reeve Toby B. | Zendy; Cros JeanPhilippe | Zendy; Gennari Cesare | Zendy; Piarulli Umberto | Zendy; de Vries Johannes G. | Zendy

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A Practical Approach to the Resolution of Racemic N ‐Benzyl α‐Amino Acids by Liquid–Liquid Extraction with a Lipophilic Chiral Salen–Cobalt( III ) Complex

Author(s) -

Reeve Toby B.,

Cros JeanPhilippe,

Gennari Cesare,

Piarulli Umberto,

de Vries Johannes G.

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200504116

Subject(s) - enantiomer , cobalt , chemistry , extraction (chemistry) , yield (engineering) , enantiomeric excess , amino acid , resolution (logic) , reactivity (psychology) , selectivity , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis , enantioselective synthesis , computer science , materials science , biochemistry , medicine , alternative medicine , pathology , artificial intelligence , metallurgy

Liquidating the assets : Coordination of one enantiomer from a racemic mixture of N ‐benzyl α‐amino acids ( N ‐Bn‐AA) to the lipophilic chiral [Co III (salen)(OAc)] complex results in its extraction into the organic phase. The enantiomer can then be released in excellent yield and high enantiomeric excess by reductive counterextraction. The cobalt( III ) complex can be regenerated and re‐used without loss of reactivity or selectivity.

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