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Highly Efficient Photolabile Protecting Groups with Intramolecular Energy Transfer
Author(s) -
Wöll Dominik,
Smirnova Julia,
Pfleiderer Wolfgang,
Steiner Ulrich E.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504091
Subject(s) - intramolecular force , covalent bond , protecting group , chemistry , photochemistry , energy transfer , excitation , stereochemistry , organic chemistry , physics , chemical physics , alkyl , quantum mechanics
Brought to light : The light sensitivity of photolabile protecting groups of the nitrophenylpropoxycarbonyl (NPPOC) type was enhanced by up to a factor of 25. This was achieved by covalently linking the protecting group to a sensitizer with a much better absorptivity and the ability to transfer its electronic excitation to the protecting group (see scheme).