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Reactivity‐Based One‐Pot Synthesis of the Tumor‐Associated Antigen N3 Minor Octasaccharide for the Development of a Photocleavable DIOS‐MS Sugar Array
Author(s) -
Lee JinqChyi,
Wu ChungYi,
Apon Junefredo V.,
Siuzdak Gary,
Wong ChiHuey
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200504067
Subject(s) - reactivity (psychology) , chemistry , linker , mass spectrometry , minor (academic) , combinatorial chemistry , covalent bond , sugar , computer science , organic chemistry , chromatography , operating system , medicine , alternative medicine , pathology , political science , law
Sweet and light : Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one‐pot strategy to synthesize the tumor‐associated carbohydrate antigen N3 minor ( 1 ). The target molecule was attached covalently to a porous silicon surface through a photocleavable linker for direct characterization in a mass spectrometer equipped with a laser source.