Reactivity‐Based One‐Pot Synthesis of the Tumor‐Associated Antigen N3 Minor Octasaccharide for the Development of a Photocleavable DIOS‐MS Sugar Array | Zendy

Lee JinqChyi | Zendy; Wu ChungYi | Zendy; Apon Junefredo V. | Zendy; Siuzdak Gary | Zendy; Wong ChiHuey | Zendy

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Reactivity‐Based One‐Pot Synthesis of the Tumor‐Associated Antigen N3 Minor Octasaccharide for the Development of a Photocleavable DIOS‐MS Sugar Array

Author(s) -

Lee JinqChyi,

Wu ChungYi,

Apon Junefredo V.,

Siuzdak Gary,

Wong ChiHuey

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200504067

Subject(s) - reactivity (psychology) , chemistry , linker , mass spectrometry , minor (academic) , combinatorial chemistry , covalent bond , sugar , computer science , organic chemistry , chromatography , operating system , medicine , alternative medicine , pathology , political science , law

Sweet and light : Readily available thioglycosides with defined relative reactivity values were used as building blocks in a one‐pot strategy to synthesize the tumor‐associated carbohydrate antigen N3 minor ( 1 ). The target molecule was attached covalently to a porous silicon surface through a photocleavable linker for direct characterization in a mass spectrometer equipped with a laser source.

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