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Reductive Modification of a Methionine Residue in the Amyloid‐β Peptide
Author(s) -
Kadlcik Vojtech,
SicardRoselli Cécile,
HouéeLevin Chantal,
Kodicek Milan,
Ferreri Carla,
Chatgilialoglu Chryssostomos
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503942
Subject(s) - peptide , radical , residue (chemistry) , methionine , chemistry , sulfur , aqueous solution , amino acid , biochemistry , stereochemistry , organic chemistry
A radical change : A chemical modification of the amyloid‐β (Aβ) peptide transformed methionine residue 35 in α‐aminobutyric acid. Hydrogen atoms produced by γ irradiation of aqueous solutions selectively attack Met 35, with formation of the modified peptide (see scheme) and sulfur‐centered radicals. By using a peptide–liposome model, the formation of trans ‐lipids has also been evaluated as a marker for this radical damage.