Reductive Modification of a Methionine Residue in the Amyloid‐β Peptide | Zendy

Kadlcik Vojtech | Zendy; SicardRoselli Cécile | Zendy; HouéeLevin Chantal | Zendy; Kodicek Milan | Zendy; Ferreri Carla | Zendy; Chatgilialoglu Chryssostomos | Zendy

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Reductive Modification of a Methionine Residue in the Amyloid‐β Peptide

Author(s) -

Kadlcik Vojtech,

SicardRoselli Cécile,

HouéeLevin Chantal,

Kodicek Milan,

Ferreri Carla,

Chatgilialoglu Chryssostomos

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503942

Subject(s) - peptide , radical , residue (chemistry) , methionine , chemistry , sulfur , aqueous solution , amino acid , biochemistry , stereochemistry , organic chemistry

A radical change : A chemical modification of the amyloid‐β (Aβ) peptide transformed methionine residue 35 in α‐aminobutyric acid. Hydrogen atoms produced by γ irradiation of aqueous solutions selectively attack Met 35, with formation of the modified peptide (see scheme) and sulfur‐centered radicals. By using a peptide–liposome model, the formation of trans ‐lipids has also been evaluated as a marker for this radical damage.

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