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Remote Chiral Induction in the Organocatalytic Hydrosilylation of Aromatic Ketones and Ketimines
Author(s) -
Malkov Andrei V.,
Liddon Angus J. P. Stewart,
RamírezLópez Pedro,
Bendová Lada,
Haigh David,
Kočovský Pavel
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503941
Subject(s) - hydrosilylation , substrate (aquarium) , enantioselective synthesis , catalysis , chemistry , organic chemistry , lewis acids and bases , process (computing) , computer science , programming language , oceanography , geology
Lewis basic, metal‐free pyridyloxazolines catalyze the reduction of prochiral aromatic ketones and ketimines with Cl 3 SiH in good enantioselectivity (up to 94 % ee ). Arene–arene interactions between the substrate and the catalyst are likely to play a role in the enantiodifferentiation process.