Remote Chiral Induction in the Organocatalytic Hydrosilylation of Aromatic Ketones and Ketimines | Zendy

Malkov Andrei V. | Zendy; Liddon Angus J. P. Stewart | Zendy; RamírezLópez Pedro | Zendy; Bendová Lada | Zendy; Haigh David | Zendy; Kočovský Pavel | Zendy

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Remote Chiral Induction in the Organocatalytic Hydrosilylation of Aromatic Ketones and Ketimines

Author(s) -

Malkov Andrei V.,

Liddon Angus J. P. Stewart,

RamírezLópez Pedro,

Bendová Lada,

Haigh David,

Kočovský Pavel

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503941

Subject(s) - hydrosilylation , substrate (aquarium) , enantioselective synthesis , catalysis , chemistry , organic chemistry , lewis acids and bases , process (computing) , computer science , programming language , oceanography , geology

Lewis basic, metal‐free pyridyloxazolines catalyze the reduction of prochiral aromatic ketones and ketimines with Cl 3 SiH in good enantioselectivity (up to 94 % ee ). Arene–arene interactions between the substrate and the catalyst are likely to play a role in the enantiodifferentiation process.

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