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Copper‐Catalyzed Reaction Cascade: Direct Conversion of Alkynes into N ‐Sulfonylazetidin‐2‐imines
Author(s) -
Whiting Matthew,
Fokin Valery V.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503936
Subject(s) - catalysis , cascade , surface modification , cascade reaction , combinatorial chemistry , azetidine , chemistry , copper , reaction conditions , component (thermodynamics) , organic chemistry , physics , chromatography , thermodynamics
Selective conversion, take three : Densely functionalized azetidine derivatives are formed in an experimentally simple three‐component catalytic procedure through the highly selective reaction of readily available terminal alkynes under mild conditions (see scheme). The azetidinimine products are remarkably stable to a wide range of reaction conditions and readily undergo further functionalization.