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Decomposition of Thymidine by Low‐Energy Electrons: Implications for the Molecular Mechanisms of Single‐Strand Breaks in DNA
Author(s) -
Ptasińska Sylwia,
Denifl Stephan,
Gohlke Sascha,
Scheier Paul,
Illenberger Eugen,
Märk Tilmann D.
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503930
Subject(s) - decomposition , thymidine , dna , electron , chemical physics , low energy , chemistry , biophysics , atomic physics , physics , biology , nuclear physics , biochemistry , organic chemistry
The damage to biological systems by high‐energy quanta occurs mainly through secondary species created in the ionization path. Interaction of the low‐energy (0–3 eV) electrons with thymidine (Td) in the gas phase was investigated. These electrons induce loss of hydrogen from the N3 position and scission of the N1C1 bond. The transfer of excess electrons, initially localized on thymine, to the sugar moiety was not observed.