Visible Sensing of Nucleic Acid Sequences with a Genetically Encodable Unmodified RNA Probe | Zendy

Narita Atsushi | Zendy; Ogawa Kazumasa | Zendy; Sando Shinsuke | Zendy; Aoyama Yasuhiro | Zendy

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Visible Sensing of Nucleic Acid Sequences with a Genetically Encodable Unmodified RNA Probe

Author(s) -

Narita Atsushi,

Ogawa Kazumasa,

Sando Shinsuke,

Aoyama Yasuhiro

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503836

Subject(s) - molecular beacon , rna , dna , rnase p , nucleic acid , computational biology , translation (biology) , gene , sequence (biology) , nucleotide , messenger rna , biology , nucleic acid sequence , microbiology and biotechnology , genetics , chemistry , oligonucleotide

Sensing DNA with RNA : Simple and sensitive DNA sensing was achieved by using an RNA probe which is composed of a molecular‐beacon‐like cis ‐repressing sequence and a gene for the reporter protein. The RNase H activity coupled molecular‐beacon–mRNA system enabled visible sensing of the target nucleotide sequence in a cell‐free translation solution (see picture).

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