Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA | Zendy

Weizmann Yossi | Zendy; Cheglakov Zoya | Zendy; Pavlov Valeri | Zendy; Willner Itamar | Zendy

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Autonomous Fueled Mechanical Replication of Nucleic Acid Templates for the Amplified Optical Detection of DNA

Author(s) -

Weizmann Yossi,

Cheglakov Zoya,

Pavlov Valeri,

Willner Itamar

Publication year - 2006

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.200503810

Subject(s) - nucleic acid , fluorophore , dna , chemistry , replication (statistics) , bond cleavage , fluorescence , template , combinatorial chemistry , nanotechnology , biochemistry , biology , materials science , physics , catalysis , quantum mechanics , virology

Fuel for a DNA machine : A FokI enzyme/DNA scission machine is triggered by the hybridization of its DNA hairpin structure with a target nucleic acid. The machine is fueled by a secondary fluorophore (F)‐ and quencher (Q)‐functionalized nucleic acid 2 . Scission of 3 leads to replication of the machinery cutter 1 and yields a fluorescent product 6 , which provides an optical output for the machine (see scheme).

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