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Highly Diastereo‐ and Enantioselective Copper‐Catalyzed Domino Reduction/Aldol Reaction of Ketones with Methyl Acrylate
Author(s) -
Deschamp Julia,
Chuzel Olivier,
Hannedouche Jérôme,
Riant Olivier
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503791
Subject(s) - stereocenter , aldol reaction , domino , enantioselective synthesis , chemistry , acrylate , alkyl , aryl , copper , catalysis , ligand (biochemistry) , organic chemistry , combinatorial chemistry , copolymer , polymer , biochemistry , receptor
A good choice : A new catalytic method was found for the construction of stereogenic quaternary carbon centers through a copper‐catalyzed domino conjugated reduction/aldol reaction of methyl acrylate with various alkyl aryl ketones. The proper choice of the chiral diphosphine ligand leads to high chemo‐, diastereo‐, and enantioselectivity.