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Direct Protein Identification from Nonspecific Peptide Pools by High‐Accuracy MS Data Filtering
Author(s) -
An Thieu Vinh,
Kirsch Dieter,
Flad Thomas,
Müller Claudia,
Spengler Bernhard
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503787
Subject(s) - identification (biology) , proteome , computational biology , peptide , chromatography , computer science , peptide mass fingerprinting , mass spectrometry , data mining , chemistry , proteomics , biology , biochemistry , gene , botany
Validate your results! High‐accuracy mass spectrometric analysis and composition‐based de novo sequencing (CBS) combined with database(DB)‐assisted protein identification allows for the rapid production of validated analytical results in proteome research. A simplified sample preparation scheme is sufficient to provide for reliable identification of proteins even when following nonspecific and unknown degradation processes.