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Straightforward One‐Pot Synthesis of Trifluoromethyl Sulfonium Salts
Author(s) -
Magnier Emmanuel,
Blazejewski JeanClaude,
Tordeux Marc,
Wakselman Claude
Publication year - 2006
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.200503776
Subject(s) - sulfonium , trifluoromethylation , reagent , trifluoromethyl , electrophile , nucleophile , aryl , chemistry , substrate (aquarium) , organic chemistry , combinatorial chemistry , salt (chemistry) , catalysis , alkyl , oceanography , geology
Mix and wait : Trifluoromethyl sulfonium salts that are able to react as reagents in the trifluoromethylation of various nucleophiles are formed in a multicomponent reaction. The desired electrophilic reagents are prepared from an aryl substrate, trifluoromethanesulfonic anhydride, and potassium trifluoromethanesulfinate in a one‐pot procedure (see scheme).